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Selection analysis identifies significant mutational changes in Omicron
Mon, 06 Dec 2021 - 15:45

CIDRI-Africa investigators post preliminary discussion comparing evolutionary patterns at sites where Omicron has differences from the Wuhan-Hu-1 reference genome, most other SARS-CoV-2 lineages, and closely related non-human sarbecoviruses.

Head-and-shoulders photo of Prof. Graeme Meintjes
Scientific Leadership Prize for Graeme Meintjes
Mon, 06 Dec 2021 - 09:15

Professor Graeme Meintjes has been awarded the 2020 European & Developing Countries Clinical Trials Partnership (EDCTP) Scientific Leadership Prize for his significant contribution to the improved understanding of HIV and its complications.

CIDRI-Africa on high alert following detection of Omicron variant
Sun, 28 Nov 2021 - 11:30

We are increasing our sequencing and SGTF monitoring to track the spread of this VOC.

In remembrance: Siphokazi Hlungulu
Mon, 22 Nov 2021 - 12:00

It is with immense sadness that we inform you of the passing of our colleague, Ms Siphokazi Hlungulu (36), on Sunday, 14 November 2021.

Super Resolution image of CD4 clusters at the surface of a lymphocyte (cyan), and bound HIV particles (Immunolabelled HIV p17, magenta [SR] and yellow [Diffraction-limited TIRF]) Credit: Caron Jacobs
Grant to boost bioimaging in Africa
Tue, 16 Nov 2021 - 09:30

Two groups at the University of Cape Town (UCT) have been awarded grants by the Chan Zuckerberg Initiative (CZI) to expand access to and expertise in bioimaging and microscopy throughout Africa. These three-year grants will enable the Electron Microscope Unit and the African BioImaging Consortium, both based at UCT, to invest in education, training and networking opportunities to serve the scientific community throughout the continent.

Person wearing gloves and labelling tubes in a laboratory
T cells face off against variants to boost COVID-19 immunity
Thu, 12 Aug 2021 - 12:00

With the fight against COVID-19 beset with concerns around the efficacy of vaccines in the face of a mutating virus, University of Cape Town virologists have shown that the body’s T cells maintain 85% of their capacity to detect variants, continuing to mount a substantial defence to prevent severe illness, hospitalisation and death.

An icon of a medicine capsule on a two-tone blue background
HIV infection may be driving drug resistance in tuberculosis
Thu, 12 Aug 2021 - 09:00

Results published today in The Lancet Microbe detail analysis of 10 years’ health data, showing a relationship between HIV infection and acquisition of rifampicin resistance by tuberculosis. Rifampicin is an important first-line anti-tuberculosis medication.

The storm after the calm: the alpha, beta and gamma variants of SARS-CoV-2 are converging on similar adaptive endpoints
Mon, 02 Aug 2021 - 09:15

Ongoing adaptive evolutionary convergence of the alpha, beta and gamma variants could lead to additional variants displaying any combination of increased transmissibility, altered virulence and/or increased capacity to escape population immunity.

People with diabetes at risk of severe COVID-19, study confirms
Tue, 20 Jul 2021 - 09:00

A recent study from the University of Cape Town (UCT) confirmed that people living with diabetes (PLWD) are at an increased risk of severe COVID‑19 (hospitalisation and mortality). The findings were published in the journal Diabetes Research and Clinical Practice.

Investigating the dynamic inflammatory profile of tuberculosis patients with and without HIV-1 co-infection
Mon, 24 May 2021 - 08:30

Increased IL-17A network connectivity serves as an indicator of elevated systemic inflammation and immune activation induced by advanced HIV infection, and predicts mortality in patients with HIV-tuberculosis co-infection.

Fire affecting the Rondebosch campus of the University of Cape Town (UCT)
Mon, 19 Apr 2021 - 12:00

No classes, tutorials, laboratory work or tests will take place on Monday, 19 April or Tuesday, 20 April. For safety reasons, campus will be locked down and no one, other than emergency services, will be allowed access.

CIDRI-Africa enrolls first patient in the MESA-TB study
Wed, 14 Apr 2021 - 11:45

The phase 2 study will evaluate the safety and immunogenicity of the M72/AS01E TB vaccine in people living with HIV.