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Contributing Investigators

Contributing Investigators: Platform Academics

Assoc. Prof. Suraj Parihar
Associate Professor Suraj Parihar
Senior Research Officer - Basic Science Platform

Associate Professor Parihar is an immunologist with interest in host-pathogen interactions during infectious diseases, particularly tuberculosis and listeriosis. His research focuses on host-directed therapies as alternative and innovative strategies. He aims to identify and validate new drug targets against tuberculosis, using repurposed drugs and chemical activators/inhibitors, as well as by gene knockdown in human/mouse macrophages and gene-deficient murine models. He studies macrophage intrinsic killing functions against M. tuberculosis and L. monocytogenes for mechanistic insights since these pathogens manipulate host cell machinery to survive within cells. He aims to increase the fundamental knowledge of macrophage infection biology by combining experimental models and infected patient materials. For that, he combines diverse tools such as deep-CAGE transcriptomics, metabolomics, systems biology, flow cytometry and confocal microscopy. Suraj was awarded ICGEB, Claude Leon Foundation, CIDRI, and Global Health Innovative Technology (GHIT) Fund-Japan funding during his post-doctoral tenure.

Assoc. Prof. Nicki Tiffin
Associate Professor Nicki Tiffin
Biomedical Data Integration Platform

Associate Professor Tiffin started her research career in molecular genetics at UCT, followed by a PhD in molecular oncology at the University of London and a postdoctoral fellowship in endocrinology research at UCSF. She continued in medical genomics and bioinformatics, and was a Principal Investigator at the South African National Bioinformatics Institute focusing on computational approaches to disease gene identification and the genetics of disease in African populations—developing computational approaches to prioritising candidate aetiological genes from the output of genome-wide analyses; as well as undertaking exome sequencing projects to identify rare aetiological variants in families with inherited diseases. During this time Nicki also addressed ethical issues relating to genome studies undertaken in African populations. She has completed a Masters in Public Health (Epidemiology), and worked at the Centre for Infectious Disease Epidemiology and Research (CIDER), contributing to the development of the Provincial Health Data Centre.

Dr Sean Wasserman
Associate Professor Sean Wasserman
Senior Medical Research Officer - Clinical Research Platform

Dr Sean Wasserman completed his medical degree as well as post-graduate training at the University of Cape Town. He is a Fellow of the College of Physicians and Infectious Diseases at the Colleges of Medicine of South Africa. Dr Wasserman is a Consultant and Associate Professor in the Division of Infectious Diseases and HIV Medicine at Groote Schuur Hospital and the University of Cape Town. He is a Contributing Investigator at CIDRI-Africa, where his two main research areas are new and repurposed drugs for tuberculosis (TB), with a focus on pharmacokinetics (PK) and resistance, and novel regimens and PK in TB meningitis. Other interests include HIV-associated Pneumocystis pneumonia, Staphylococcus aureus bacteraemia, and antibiotic stewardship. Sean is a member of the original cohort of the International Society for Infectious Diseases (ISID) Emerging Leaders Program and has recently been elected onto the ISID Council. He was awarded the TB Union’s Stephen Lawn TB-HIV Research Leadership Prize for 2019, as well as the Institut Mérieux and Infectious Diseases Society of Southern Africa Young Investigator Award for research in antibiotic stewardship.

Contributing Investigator

Expertise/research field

Associate Professor Wendy Burgers

HIV, cellular immunology, HIV/TB co-infection, vaccines, mucosal immunology

Dr Anna Coussens

Immunology of TB and HIV-associated TB

Associate Professor Helen Cox

Epidemiology, TB, drug-resistance, treatment, diagnosis

Professor Collet Dandara

Pharmacogenomics of antiretrovirals and other anti-infectives

Paediatric HIV and TB research

Professor Keertan Dheda

Clinical, transmission, genomic and epidemiological aspects of respiratory infections including TB, and the development and validation of user-friendly point-of-care diagnostics.

Haem detoxification pathway in Plasmodium falciparum, effects of antimalarials on this pathway; interactions of antimalarials with haem in solution and the solid state

Associate Professor Reto Guler

Host-directed drug therapy of TB, murine studies of other intracellular pathogens such as leishmaniasis and listeriosis

Professor Mark Hatherill

TB vaccines and clinical trials

Associate Professor William Horsnell

Host immunity to helminths, pulmonary immunity

Dr Jennifer Claire Hoving

Host immune responses to disease, with a particular focus on HIV-related fungal infections and M. tuberculosis

Associate Professor Marvin Hsiao

Health systems related to laboratories, HIV infection in infants, and molecular assay evaluation

Professor Muazzam Jacobs

Murine models of intracellular infection, especially TB

Associate Professor Heather Jaspan

Paediatric infectious diseases, HIV, vaccine immunogenicity, infant feeding, adolescent mucosal immunology, mucosal microbiome

Supervised learning as related to cytokine and other biomarker assay profiles, particularly in TB disease progression and Bayesian mixture models for longitudinal HIV viral load data

Dr Mohlopheni Marakalala

Host factors driving immunopathogenesis during TB progression using molecular histology techniques; mycobacterial genes for host survival

Associate Professor Darren Martin

Evolution of viruses

Infectious diseases (HIV/AIDS, TB and sexually transmitted infections); women’s health; social determinants of health

Professor Mpiko Ntsekhe

Cardiovascular disease; tuberculous pericarditis

Professor Ntobeko Ntusi

Cardiomyopathies; inflammatory heart disease

Associate Professor Tolullah Oni

Health services research, particularly in the context of co-morbidities between common infectious and non-communicable diseases

Associate Professor Jo-Ann Passmore

HIV/HPV mucosal immunology, genital tract, innate immunity, cytokine biomarkers, genital tract immune activation

Associate Professor Molebogeng Rangaka

Translational research in the diagnosis and prevention of tuberculosis in vulnerable populations; digital health innovation for HIV/TB care

Dr Catherine Riou

Infectious diseases (HIV/TB), immune memory, antigen-specific responses, T cell differentiation, cytokines, signal transduction and T cell lineage commitment

Dr Georgia Schäfer

Host-pathogen interactions of Kaposi’s sarcoma herpesvirus (KSHV) and human papillomavirus (HPV), particularly in the context of HIV co-infection

Dr Muki Shey

HIV and TB; understanding reasons for resistance to TB infection in individuals with sustained exposure to TB but who remain uninfected

T cell Immunology, human TB, HIV, TB-IRIS

Professor Anna-Lise Williamson

HIV vaccine development especially via the development of live poxvirus vectors

Professor Robin Wood

Large-scale interventions against, and understanding the transmission of, TB & HIV

Professor Heather Zar

Paediatric lung health

Professor Liesl Zühlke

Paediatric cardiology