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HIV-1 and TB co-infection skew the SARS-CoV-2 T cell response
SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associate with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression.
Image of scientist holding up a Petri dish
Supporting Excellence
The Wellcome Centre for Infectious Diseases Research in Africa fosters investigator-led approaches via the overarching scientific objective of combatting infection, especially HIV-1 and tuberculosis, through clinical and laboratory research.
Macrophages infected with M. tuberculosis; image by Dr Suraj Parihar
Basic Science
Our Basic Science Platform provides the laboratory infrastructure and technical support to ensure the safe handling of infectious material.
Subgraph of the ANIMA network for dataset HIVsetB
Biomedical Data Integration
We work with multidimensional clinical and scientific data at the molecular, cellular, clinical and population levels.
Image of a researcher and study participant reading an informed consent document
Clinical Research
CIDRI-Africa supports clinical studies in the community at our facility at Site B in Khayelitsha.

News

Friday, 26 November 2021
In remembrance: Siphokazi Hlungulu

It is with immense sadness that we inform you of the passing of our colleague, Ms Siphokazi Hlungulu (36), on Sunday, 14 November 2021.

Publication Date:
Mon, 22 Nov 2021 - 12:00
Super Resolution image of CD4 clusters at the surface of a lymphocyte (cyan), and bound HIV particles (Immunolabelled HIV p17, magenta [SR] and yellow [Diffraction-limited TIRF]) Credit: Caron Jacobs
Grant to boost bioimaging in Africa

Two groups at the University of Cape Town (UCT) have been awarded grants by the Chan Zuckerberg Initiative (CZI) to expand access to and expertise in bioimaging and microscopy throughout Africa. These three-year grants will enable the Electron Microscope Unit and the African BioImaging Consortium, both based at UCT, to invest in education, training and networking opportunities to serve the scientific community throughout the continent.

Publication Date:
Tue, 16 Nov 2021 - 09:30
Person wearing gloves and labelling tubes in a laboratory
T cells face off against variants to boost COVID-19 immunity

With the fight against COVID-19 beset with concerns around the efficacy of vaccines in the face of a mutating virus, University of Cape Town virologists have shown that the body’s T cells maintain 85% of their capacity to detect variants, continuing to mount a substantial defence to prevent severe illness, hospitalisation and death.

Publication Date:
Thu, 12 Aug 2021 - 12:00
An icon of a medicine capsule on a two-tone blue background
HIV infection may be driving drug resistance in tuberculosis

Results published today in The Lancet Microbe detail analysis of 10 years’ health data, showing a relationship between HIV infection and acquisition of rifampicin resistance by tuberculosis. Rifampicin is an important first-line anti-tuberculosis medication.

Publication Date:
Thu, 12 Aug 2021 - 09:00

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